Thomas Ondra
Optimized Response-Adaptive Clinical Trials
Sequential Treatment Allocation Based on Markov Decision Problems
Paperback Engels 2014 2015e druk 9783658083434
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Samenvatting
Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.
Specificaties
ISBN13:9783658083434
Taal:Engels
Bindwijze:paperback
Aantal pagina's:102
Uitgever:Springer Fachmedien Wiesbaden
Druk:2015
Serie:BestMasters
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Inhoudsopgave
Introduction to Markov Decision Problems and Examples.- Finite and Infinite Horizon Markov Decision Problems.- Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration.- Designing Response Adaptive Clinical Trials with Markov Decision Problems.
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