Introduction to Basics of Pharmacology and Toxicology

1. Experimental methodologies involved in the discovery of drugs.- 2. Laboratory animals.- 3. Care and Handling of Laboratory Animals.- 4. Biological Sample Collection from Experimental Animals.- 5. Anaesthesia and Euthanasia of Experimental Animals.- 6. Equipment in experimental Pharmacology.- 7. Bioassay and experiments on isolated muscle preparations.- 8. Experiments on Anaesthetized Intact Animals.- 9. Bioassay of standard compounds.- 10. PRINCIPLES OF EC50, ED50, pD2 and pA2 VALUES OF DRUGS.- 11. Physiological salt solutions.- 12. Validation of animal model.- 13. Screening Methods for the Evaluation of Antidepressant Drugs.- 14. Screening methods for evaluation of antiepileptics.- 15. Screening Methods Involved in the Evaluation of General Anaesthetics.- 16. Screening methods for evaluation of anti-psychotics.- 17. Screening methods for evaluation of sedative and hypnotics.- 18. Screening Methods for the Evaluation of Anxiolytic Drugs.- 19. Screening methods for evaluation of drugs with Anti-Parkinsonism activities.- 20. Screening methods for evaluation of drugs for learning and memory.- 21. Screening Methods Involved in the Evaluation of Antianginal Agents.- 22. Screening methods involved in the evaluation of Anti-hypertensive agents.- 23. Screening methods involved in the evaluation of anti arrhythmic agents.- 24. Screening methods involved in evaluation of cardiotonic drugs (Cardiac Hypertrophy and Insufficiency/ Drugs for Heart Failure).- 25. Screening Methods for the Evaluation of Antiplatelet Drugs.- 26. Screening methods involved in the evaluation of diuretics.- 27. Screening Methods for anti-hyperlipidemic agents.- 28. Screening Methods Involved in the Evaluation of Antiulcer Drugs.- 29. Screening Methods Involved in the Evaluation of Antidiarrheal Drugs (Drugs Affecting Intestinal Motility and Secretion).- 30. Screening Methods Involved in the Evaluation of Antiemetics.- 31. Screening Methods for the Evaluation of Hepatoprotective Agents.- 32. Screening Methods for the Evaluation of Anti-obesity Drugs.- 33. Absorption studies.- 34. Screening methods for evaluation of anti-asthma agents.- 35. Screening Methods for Evaluation of Antitussives and Expectorants.- 36. Screening methods involved in the evaluation of anti-diabetic drugs.- 37. Screening Methods for the Evaluation of Antithyroid Drugs.- 38. Screening methods for evaluation of antifertility drugs.- 39. Screening methods for evaluation of Posterior Pituitary, Adrenal Steroid, Testicular, Parathyroid, Ovarian, and Thyroid Hormones.- 40. Screening methods involved in the evaluation of drugs with analgesic, anti-inflammatory, and antipyretic activity.- 41. Screening Methods Involved in the Evaluation of Drugs with Ophthalmologic Activity.- 42. SCREENING METHODS FOR THE EVALUATION OF DRUGS AFFECTING PERIPHERAL NERVE FUNCTION.- 43. MUTAGENIC TOXICITY TESTING.- 44. Screening methods for evaluation of anticancer drugs.- 45. Screening Methods Involved in the Evaluation of Drugs for Benign Prostatic Hyperplasia.- 46. Evaluation of Drugs Acting on Autonomic Nervous System.- 47. Screening Methods for the Evaluation of Antifungal, Anthelminthic, Antibacterial, and Antiviral Agents.- 48. Preclinical toxicity studies.- 49. Ethical Issues in Animal Research.- 50. Good Laboratory Practice (GLP).- 51. Basic principles and applications of simple analytical methods.- 52. Principles of Quantitative Estimation of Drugs, Endogenous Compounds, and Poisons.- 53. Principles of quantitative estimation of drugs, endogenous compounds, and poisons - 2.- 54. Plant extraction methods.- 55. Literature search.- 56. STUDY DESIGNS.- 57. Ethical Issues Related to Medical Research on Human Participants.- 58. Basic principles and application of statistics in drug research.- 59. Calculation of Basic Statistical Parameters.- 60. Hypothesis Testing.- 61. Parametric tests.- 62. NON-PARAMETRIC TESTS.- 63. Common errors in using statistical tools and data presentation.