Molecular Biology of Neuroreceptors and Ion Channels

I. Introduction.- Common Structural Principles of Ion Channel Proteins.- II. Molecular Biology of Nicotinic Acetylcholine Receptors.- Brain and Muscle Nicotinic Acetylcholine Receptors: A Gene Family.- The Gene Family Encoding Neuronal Acetylcholine Receptors: Structure of the Avian Alpha2 and Alpha3 Genes.- Structure of Muscle and Neuronal Nicotinic Acetylcholine Receptors.- Nicotinic Acetylcholine Receptors in the Nervous System of Insects.- Ligand-Gated Ion Channels of Drosophila.- III. Molecular Biology of Aminoacid Receptors.- The Structure and Expression of the GABAA Receptor as Deduced by Molecular Genetic Studies.- GABAA Receptor: Subunit Expression in Xenopus Oocytes and Localization of Receptor mRNAs in Rat Brain.- Molecular Heterogeneity of GABAA-Benzodiazepine Receptors.- The Postsynaptic Glycine Receptor — a Member of the Neurotransmitter-Gated Channel Protein Family.- Immunological Identification of a Neonatal Glycine Receptor Isotype and Its Expression in Primary Cultures of Spinal Cord.- Glycine Receptor Regulation in Rodent Spinal Cord.- Expression-Cloning and Analysis of the Serotonin 1c Receptor from Mouse Brain.- Cloned Serotonin 5HT-2 Receptor: Structure and Second Messenger Coupling.- An Apparent New L-Glutamate Receptor in the Mammalian-Peripheral Nervous System.- IV. Molecular Biology of Voltage-Gated Ion Channels.- Molecular Properties of Voltage-Sensitive Sodium and Calcium Channels.- Genetic and Molecular Analysis of a Gene Encoding Sodium Channels in Drosophila.- A Family of Potassium Channels from the Shaker Locus of Drosophila.- Molecular Basis of Biological Diversity at the Shaker Locus of Drosophila.- V. Molecular Biology of Other Neuroreceptors and Ion Channels.- Common Properties of Receptors Coupled to GTP Binding RegulatoryProteins.- Cloning of a Rat D2-Dopamine Receptor cDNA.- Molecular Characterization of Neuropeptide Receptors and of a Novel Membrane Protein Involved in K+ Permeation.- A 64 kDa Protein is a Candidate for a TRH Receptor in Prolactin-Producing Rat Pituitary Tumour Cells.- Comparison of the Presynaptic Vesicle Component Synaptophysin and GAP Junction Proteins: A Clue for Neurotransmitter Release?.- VI. Structure-Function Relationships of Ion Channel Proteins.- Use of Synthetic Peptides and High Affinity Protein Ligands for Structural Studies of Central and Peripheral Nicotinic Receptors.- Functional Domains of the Nicotinic Acetylcholine Receptor.- The Limited Sequence Specificity of Anti-Peptide Antibodies May Introduce Ambiguity in Topological Studies.- Structure, Conformation and Immunological Analysis of peptide 188–201, the Putative Binding Site for a-Bungarotoxin in the a Subunit of Acetylcholine Receptor.- Towards an Understanding and Use of the Cholinergic Binding Site.- Evidence for Multipoint Attachment of Ligands to the Nicotinic Acetylcholine Receptor.- Fine Structural Characterization of the Main Immunogenic Region of the Nicotinic Acetylcholine Receptor.- Phosphorylation of the Nicotinic Acetylcholine Receptor and Localization of its Phosphorylation Sites.- A New Bromobimane Fluorescent Label for Anion Exchange Proteins.- Changes in Membrane Phosphoproteins Associated with the ATP Modulation of the Delayed Rectifier K+ Channel in the Squid Giant Axon.- Channel Modelling Experiments in Planar Bilayers Using Amphiphilic Helical Polypeptides.- Structural and Dynamic Molecular Models for Sodium Channels.- VI. Gene Expression, Gene Regulation and Development.- Processing, Assembly, and Ligand Binding of the Mouse Nicotinic Acetylcholine Receptor Subunits inStably Transfected Fibroblasts.- Assembly and Insertion of a Multi-Subunit Nicotinic Acetylcholine Receptor into Plasma Membranes.- Stable Expression of Multisubunit Protein Complexes in Mammalian Cells.- Regulation of Acetylcholine Receptor Gene Expression During Development of the Neuromuscular Junction.- Developmental Regulation of Acetylcholine Receptor-Subunit mRNA at the Rat Neuromuscular Junction.- Myotube Specific Expression of the Mouse AChR Delta Subunit Gene is Conferred by 148 BP of 5? Flanking DNA.- Transcriptional Regulation of Acetylcholine Receptor Genes in Transfected Muscle Cells and Transgenic Mice.- The Intermediate Lobe of the Pituitary: A Model for Studying Mechanisms of Trans-Synaptic Regulation of Specific Gene Expression.- Positive Modulators of Acetylcholine Receptor: Differences Between Skeletal Muscle and Electric Organ.- Localisation of Muscarinic Acetylcholine Receptors in Cat Visual Cortex during Postnatal Development.- Regulation of Cortical Muscarinic Acetylcholine Receptors: Involvement of Potassium Channels.- Regulation of Calcium Channels and Adenylate Cyclase by Opiates.- Transdifferentiation to a Neuronal Phenotype in Adult Bovine Chromaffin Cells: Effects of ?MSH, ?FGF and Histamine.- VII. Clinical Aspects.- Molecular Biology of Neuroreceptors: Implications for Clinical Neuroscience.- Authors Index.